The serendipitous locating of an acetate ion from the crystallization answer bound in the energetic website of AlaA permitted the precise mapping of the area and orientation of the alanine substrate and the interacting catalytic residues (Determine 2C and 4A), and indicated the conformational modifications that would be needed for the productive binding of two-oxoglutarate or Lglutamate
Because many different amino acid aminotransferases can catalyze the interconversion in between alanine and...