Dencichine

Description:
Dencichine is an anti-inflammatory and anti-ulcer agent that has been shown to prevent oxidative injury in the bowel. The mechanism of this drug is not yet known, but it may be due to its antioxidant properties. Dencichine also has a protective effect on the epithelial cells and prevents the loss of cell-to-cell contact. This drug also has been shown to have a protective effect against bowel disease in mice. Dencichine is absorbed by the intestine, with high water permeability, and accumulates in the bowel. It inhibits intestinal inflammation by inhibiting prostaglandin synthesis, which may be due to its inhibition of cyclooxygenase or lipoxygenase activity.

Uniprot :
P03951

Description:
Chiral building block for synthesis of carbohydrate and nucleoside derivatives

Uniprot :
P60022

Description:
Decachlorobiphenyl is a chemical that is produced by the reaction of chlorine with biphenyl or diphenyl ether. Decachlorobiphenyl has been shown to inhibit the enzyme activity of fatty acid synthase in liver cells, which is responsible for synthesizing fatty acids. It also inhibits the enzyme activity of acetyl-CoA carboxylase, which is involved in regulating the production of ketone bodies and fatty acids. The mechanism of action for decachlorobiphenyl inhibition of these enzymes is thought to be due to its ability to bind to the active site and interfere with the formation of an enzyme-substrate complex. Decachlorobiphenyl can be detected using chemical ionization mass spectrometry at m/z=313 and 314, corresponding to C13H9Cl10+ and C13H9Cl7+, respectively.

Uniprot :
P09038

Description:
Eupalinilide-D is a peptide inhibitor of voltage-gated sodium channels. It is a potent, selective, and cell-permeable blocker of the high-threshold A type (I A ) and intermediate-threshold C type (I C ) sodium channels in rat dorsal root ganglion neurons. Eupalinilide-D can also inhibit the activation of voltage-gated potassium channels by blocking the binding site for GABA on the channel. Eupalinilide-D has been used as a research tool to study the effects of peptides on ion channel function in cells and animal models.

Uniprot :
P33681

Description:
Griffonilide is a plant-derived natural product that has been shown to have cytotoxic, anti-inflammatory, and immunosuppressive properties. Griffonilide is a mixture of compounds that are extracted from the culture supernatant of a fungus called Griffonia simplicifolia. It has been shown to have cytotoxic effects on cancer cells and hyperproliferative diseases such as psoriasis. Griffonilide also inhibits the growth of bacteria by binding to fatty acids in their cell membranes. The anti-bacterial activity of griffonilide is not affected by fatty acids or by eluting with water, but is inhibited by elution with protocatechuic acid.

Uniprot :
E7CIA8