NUC-7738

Description:
NUC-7738 is a medicinal compound that has been shown to be an effective inhibitor of cyclin-dependent kinases (CDKs). It has potent anticancer activity and has been studied extensively in Chinese hamster ovary (CHO) cells, human leukemia cells, and other cancer cell lines. NUC-7738 works by selectively inhibiting CDK4/6, which are critical regulators of the cell cycle. This leads to the induction of apoptosis in cancer cells, making it a promising new therapeutic agent for the treatment of various types of cancer. Additionally, NUC-7738 has been shown to have low toxicity and good pharmacokinetic properties in preclinical studies. Overall, this compound holds great promise as a novel anticancer therapy that may help improve outcomes for patients with cancer.

Description:
12-Oxocalanolide A is a natural product isolated from the genus Calophyllum inophyllum. The compound has been shown to inhibit human immunodeficiency virus (HIV) and other viruses by binding to their β-unsaturated ketone moiety. 12-Oxocalanolide A also has antimycobacterial activity, which is due to its inhibition of protein synthesis and DNA replication. The compound is biosynthesized from calanolides, which are found in the bark of the genus Calophyllum inophyllum.

Uniprot :
P14923

Uniprot :
P11532

Description:
NVP-BVU972 is a small molecule inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor. It has been shown to inhibit the growth of cancer cells in vitro and in vivo. NVP-BVU972 binds to the ATP binding site of the kinase domain and inhibits protein synthesis by preventing phosphorylation of downstream substrates. This drug also has a pharmacokinetic profile that is not affected by renal or hepatic dysfunction. NVP-BVU972 is currently being evaluated as a predictive biomarker for cancer treatment response.

Uniprot :
P46108

Description:
A light-sensitive probe that functionally encapsulates L-glutamate in an inactive form. Irradiation with light at 360-380 nm cleaves the MNI protecting group and allows the release of free L-glutamate. It allows tuneable control of the L-glutamate in neurons and precise control over time, dose and location of L-glutamate release.

Uniprot :
O95229

Description:
Hybridaphniphylline B is a quinolone alkaloid that is found in the roots of Daphniphyllum macropodum. This compound has been shown to inhibit the growth of bacteria by inhibiting protein synthesis through a diels–alder reaction. Hybridaphniphylline B is also an effective antioxidant, showing activity against lipid peroxidation and reactive oxygen species.

Uniprot :
P40126