2021, 26, x FOR PEER Evaluation Molecules 2021, 26, x FOR PEER Critique Molecules 2021, 26, x
2021, 26, x FOR PEER Evaluation Molecules 2021, 26, x FOR PEER Assessment Molecules 2021, 26, x FOR PEER REVIEWMolecules 2021, 26,four of 34 4 of 34 4 of4 of15 15 Table 1. Cont.Entry Ar-XC (24 h) C (24 h) C (24 h)Technique (Reaction Time)1f, 97 1f, 97 1f,Product (E), Yield 16 1716 1616 17 1717 18 1818 1918 1919 20 2020 21 2121 21 22 22B (24 h) B (24 h) C B (24 h) (48 h)h) B (24 C (48 h) C (48 h) C (48 h) C (48 h) C (48 h) C (48 D C (48 h) (24 h)h) D (24 h) D (24 h) C (48 h) C (48 D C (48 h) (24 h)h) D(24 h) D (24 h) D (24 D (24 h) D (24 h) D (24 D (24 h)1g, 37 1g, 1g, 37 1g, 9237 1g, 37 1g, 1g, 9292 1g, 92 1h, 80 1h, 1h, 80 1h, 80 1h, 8080 1h, 80 1h, 80 1i, 75 1i, 75 1i, 75 1i, 35 1i, 3535 1i, 1i, 35 1j, 35 1j, 1j, 3535 1j,Following purification (see experimental component); when low yields have been recorded, beginning components 1 1 Soon after purification (see experimental low yields have been recorded, have been materials were in general recovered. 1 After purification (see experimental element); when low yields have been recorded, beginning supplies After in general recovered. had been purification (see experimental part); whenpart); when low yieldsstarting recorded, starting supplies were normally recovered. were normally recovered.Regarding the double N-arylation reaction in between 7-azaindole and and 1,3-diiodobenConcerning the double N-arylation reaction among 7-azaindole 1,3-diiodobenzene, Regarding the the expected item 2k with a2k withyield (40 ) than(40 ) than MethodMethod provideddouble N-arylation reaction between 7-azaindole and 1,3-diiodobenC also C also supplied the expected item higher a higher yield Method D zene, Concerning the double N-arylation reaction between 7-azaindole and 1,3-diiodobenzene, D (15 ).C also supplied the expected productof 4 days, greater resultingresult(15 ). Even so,C also offered the expected item 2k having a greater yield2k from zene, System despite long reaction occasions of four days, the product item (40 ) than System Process On the other hand, regardless of long reaction times 2k with a the2k yield (40 ) than Technique D (15 ). However, is still long reaction occasions of 4 days, both instances) 1, resultaing from a single N-arylationdespitepresent (isolated in 20 both instances) (Scheme(Scheme single N-arylation is still present (isolated in 20 yield in yield within the product 2ktop). System D (15 ). On the other hand, regardless of long reaction occasions of 4 days, the product 2k resultBying from contrast,N-arylation is still presentthe towards the in 20 yield7-azaindole and 1,4contrast, single when C was C was applied reaction in between in both cases) (Scheme 1, top). By a when Strategy System applied to (isolated reaction GYKI 52466 Technical Information involving 7-azaindole and diiodobenzene, the the anticipated solution was this time obtained having a a higher 80 yield 1, leading). By contrast, when Strategy C was2l was this timereaction in between 7-azaindole and 1, leading). By contrast, when Method C 2l applied towards the obtained with high 80 yield 1,4-diiodobenzene, anticipated item was applied for the reaction involving 7-azaindole and 1,4-diiodobenzene, (Scheme 1, bottom). the anticipated product 2l was this time obtained having a high 80 yield 1,4-diiodobenzene, (Scheme 1, bottom). the anticipated solution 2l was this time obtained with a high 80 yield (Scheme 1, bottom). (Scheme 1, bottom).Scheme 1. 1-Arylation reactions between 7-azaindole and 1,3- or 1,4-diodobenzene. Scheme 1. 1-Arylation reactions IQP-0528 In Vivo amongst 7-azaindole and 1,3- or 1,4-diodobenzene. Scheme 1. 1-Arylation reactions involving 7-azaindole and 1,3- or 1,4-diodobenzene. Scheme 1. 1-A.
