Aconitine
Aconitine is a toxin found in Aconitum that exhibits antipyretic, antihypertensive, analgesic, and antinociceptive activities. Aconitine binds neurotoxin binding site 2 of Na+ channels, forcing the channel to stay open longer, allowing continual depolarization, Na+ influx, and eventually paralysis. Aconitine acts as a positive inotrope, potentially inducing cardiac arrhythmia.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18835794
| Cas No. |
302-27-2 |
|---|---|
| Purity |
≥88% |
| Formula |
C34H47NO11 |
| Formula Wt. |
645.74 |
| Chemical Name |
(1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy- 4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate |
| Synonym |
20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diyl 8-acetate 14-benzoate: Acetylbenzoylaconine |
| Melting Point |
204°C |
| Solubility |
Soluble in water (0.3mg/mL) or ethanol (35mg/mL). |
| Appearance |
White Crystal |
Chan TY. Aconite poisoning. Clin Toxicol (Phila). 2009 Apr;47(4):279-85. PMID: 19514874.
Gutser UT, Friese J, Heubach JF, et al. Mode of antinociceptive and toxic action of alkaloids of Aconitum spec. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):39-48. PMID: 9459571.
Okazaki M, Kimura I, Kimura M. Aconitine-induced increase and decrease of acetylcholine release in the mouse phrenic nerve-hemidiaphragm muscle preparation. Jpn J Pharmacol. 1994 Dec;66(4):421-6. PMID: 7723217.
