Acemetacin
Acemetacin is a glycolic acid ester prodrug of indomethacin; it is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2, decreasing production of thromboxane B2 (TxB2) and prostaglandin E2 (PGE2). Acemetacin is clinically used to treat rheumatoid arthritis, osteoarthritis, and post-operative pain. In vitro, acemetacin also exhibits antioxidative activity, scavenging ROS and RNS.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18835577
| Cas No. |
53164-05-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C21H18ClNO6 |
| Formula Wt. |
415.83 |
| Chemical Name |
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester |
| IUPAC Name |
2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyaceticacid |
| Synonym |
Acemix; Emflex; Rantudil; Solart |
| Melting Point |
150-153°C |
| Solubility |
Soluble in DMSO. |
| Appearance |
Slightly Yellowish Crystalline Powder |
Chávez-Piña AE, McKnight W, Dicay M, et al. Mechanisms underlying the anti-inflammatory activity and gastric safety of acemetacin. Br J Pharmacol. 2007 Nov;152(6):930-8. PMID: 17876306.
Fernandes E, Costa D, Toste SA, et al. In vitro scavenging activity for reactive oxygen and nitrogen species by nonsteroidal anti-inflammatory indole, pyrrole, and oxazole derivative drugs. Free Radic Biol Med. 2004 Dec 1;37(11):1895-905. PMID: 15528048.
