Ac-SDKP
Ac-SKDP is a pro-angiogenic peptide degradation product of thymosin B4 that regulates hematopoiesis by inhibiting proliferation of hematopoietic pluripotent stem cells (spleen colony-forming units, or CFUs). This peptide exhibits cardioprotective, anti-inflammatory, and anti-fibrotic activities. In animal models of chronic myocardial infarction, Ac-SDKP improves left ventricular function, increases angiogenesis, and decreases infarct size. In hypertensive rats, Ac-SDKP prevents angiotensin II-induced increases in collagen synthesis and cross-linking as well as expression of LOX and TGF-β and activation of NF-κB and lymphocytic immune cells. In other animal models, this peptide prevents fibrosis, decreasing deposition of fibronectin and collagen and decreasing the number of myofibroblasts and macrophages. Ac-SDKP also exhibits nephroprotective activity, inhibiting progression of lupus nephritis in animal models; Ac-SDKP decreases proteinuria, infiltration of inflammatory T cells and macrophages, production of TNF-α, activation of NF-κB, and phosphorylation of Smad2/3, resulting in improvements in renal function.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18835430
| Cas No. |
120081-14-3 |
|---|---|
| Purity |
≥95% |
| Formula |
C20H33N5O9 |
| Formula Wt. |
487.51 |
| IUPAC Name |
(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylic acid |
| Synonym |
Goralatide |
| Appearance |
White to off white powder |
Song M, Jang H, Lee J, et al. Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP. Biomaterials. 2014 Mar;35(8):2436-45. PMID: 24378015.
González GE, Rhaleb NE, Nakagawa P, et al. N-acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats. Clin Sci (Lond). 2014 Jan 1;126(1):85-94. PMID: 23834332.
Zuo Y, Chun B, Potthoff SA, et al. Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis. Kidney Int. 2013 Dec;84(6):1166-75. PMID: 23739235.
Tan H, Zhao J, Wang S, et al. Ac-SDKP ameliorates the progression of lupus nephritis in MRL/lpr mice. Int Immunopharmacol. 2012 Dec;14(4):401-9. PMID: 22922317.
Lenfant M, Wdzieczak-Bakala J, Guittet E, et al. Inhibitor of hematopoietic pluripotent stem cell proliferation: purification and determination of its structure. Proc Natl Acad Sci U S A. 1989 Feb;86(3):779-82. PMID: 2915977.
