4-Thiouridine
4-Thiouridine is a modified nucleotide that induces DNA cross-linking after irradiation with UV light. This compound is often used for labeling DNA in research models.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18834282
| Cas No. |
13957-31-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C9H12N2O5S |
| Formula Wt. |
260.27 |
| Chemical Name |
Uridine, 4-thio- (8CI)(9CI) |
| IUPAC Name |
1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one |
| Synonym |
Thiouridine |
| Melting Point |
141-143°C |
| Solubility |
water |
| Appearance |
Yellowish crystalline powder |
Wang L, Ruffner DE. An ultraviolet crosslink in the hammerhead ribozyme dependent on 2-thiocytidine or 4-thiouridine substitution. Nucleic Acids Res. 1997 Nov 1;25(21):4355-61. PMID: 9336468.
Ofengand J, Liou R, Kohut J 3rd, et al. Covalent cross-linking of transfer ribonucleic acid to the ribosomal P site. Mechanism and site of reaction in transfer ribonucleic acid. Biochemistry. 1979 Oct 2;18(20):4322-32. PMID: 385051.
