2-Deoxy-D-glucose
2-deoxy-D-glucose inhibits glucose metabolism and is used as a biomarker of glucose metabolism, hypoxia, and angiogenesis in a variety of models and cell types, including neurotoxicity, cancer, and autoimmune disease; the 2-OH group of glucose is replaced by a hydrogen and therefore this compound can not be metabolized properly. 2-deoxy-D-glucose inhibits N-linked glycosylation and glycolysis, inhibiting surface expression of MICA/B and other NKG2D ligands on cells. This compound also exhibits anticancer and pro-oxidative activities, increasing oxidative stress and mimicking glucose deprivation, resulting in cell death of cancer cells.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18832033
| Cas No. |
154-17-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C6H12O5 |
| Formula Wt. |
164.16 |
| IUPAC Name |
(2S,4S,5S,6S)-6-(hydroxymethyl)oxane-2,4,5-triol |
| Melting Point |
146-147°C |
| Appearance |
White to slight yellow powder |
product targets : sFRP-1 inhibitors
Kaira K, Murakami H, Endo M, et al. Biological correlation of (18)F-FDG uptake on PET in pulmonary neuroendocrine tumors. Anticancer Res. 2013 Oct;33(10):4219-28. PMID: 24122985.
Andresen L, Skovbakke SL, Persson G, et al. 2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation. J Immunol. 2012 Feb 15;188(4):1847-55. PMID: 22227571.
Shutt DC, ODorisio MS, Aykin-Burns N, et al. 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells. Cancer Biol Ther. 2010 Jun 1;9(11):853-61. PMID: 20364116.
Nowak M, Carrasquillo JA, Yarboro CH, et al. A pilot study of the use of 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography to assess the distribution of activated lymphocytes in patients with systemic lupus erythematosus. Arthritis Rheum. 2004 Apr;50(4):1233-8. PMID: 15077306.
Böhmer R, Rommel K. The behaviour of different markers of the mucosal extracellular space in rat small intestine. Acta Hepatogastroenterol (Stuttg). 1975 Dec;22(6):398-403. PMID: 1211066.
