15-Acetyl-deoxynivalenol
15-acetyl deoxynivalenol (15-A-DON) a type A trichothecene mycotoxin initially produced by species of Fusarium. 15-A-DON is typically found in grains used for livestock feed as well as human consumption, such as cereal and bread. This compound exhibits potential anticancer and immunomodulatory benefit in vitro, upregulating IL-8 production and inducing apoptosis in Jurkat T cells. 15-A-DON also displays biphasic effects on cytokine production in CD4+ T cells, initially decreasing expression of IL-2, IL-4, and IL-5, then increasing expression of all three after 7 days of exposure.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18831740
| Cas No. |
88337-96-6 |
|---|---|
| Purity |
≥98%, TLC |
| Formula |
C17H22O7 |
| Formula Wt. |
338.35 |
| Synonym |
15-Acetyl-deoxynivalenol15-A-DON |
| Melting Point |
185-187°C |
| Solubility |
Soluble in acetonitrile, methanol and ethyl acetate, only slightly soluble in water. |
| Appearance |
White crystalline solid |
product targets : Xanthine Oxidase inhibitors
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Monbaliu S, Van Poucke C, Detavernier C, et al. Occurrence of mycotoxins in feed as analyzed by a multi-mycotoxin LC-MS/MS method. J Agric Food Chem. 2010 Jan 13;58(1):66-71. PMID: 19994896.
Gottschalk C, Barthel J, Engelhardt G, et al. Occurrence of type A trichothecenes in conventionally and organically produced oats and oat products. Mol Nutr Food Res. 2007 Dec;51(12):1547-53. PMID: 18030660.
Pestka JJ, Uzarski RL, Islam Z. Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes. Toxicology. 2005 Jan 15;206(2):207-19. PMID: 15588914.
Ouyang YL, Azcona-Olivera JI, Pestka JJ. Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells. Toxicology. 1995 Dec 15;104(1-3):187-202. PMID: 8560498.
