Et al. BMC Genomics 2014, 15:159 http:www.biomedcentral.com1471-216415Page 13 ofDSA performed the microarray hybridization evaluation. DSA conceived in the study, participated in its design and coordination and helped to draft the manuscript. All authors read and authorized the final manuscript. Acknowledgements Supported by National Institutes of Well being grant R21AI075237 and R01AI072297 to DSA. The authors thank Jay Card for photography and illustration assistance. Author details 1 Department of Pathology Laboratory Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0529, USA. two Division of Biomedical Informatics, Cincinnati Children’s Hospital Analysis Foundation, Cincinnati, OH 45229, USA. 3The J. Craig Venter Mitochondrial fusion promoter M1 Data Sheet Institute, 9704 Health-related Center Drive, Rockville, MD 20850, USA. 4Department of Pathology, University of Cincinnati, PO Box 670529, Cincinnati, OH 45267-0529, USA. Received: 17 October 2013 Accepted: 17 February 2014 Published: 25 February 2014 References 1. Shoham S, Marr KA: Invasive fungal infections in strong organ transplant recipients. Future Microbiol 2012, 7(five):63955. 2. Segal BH: Aspergillosis. N Engl J Med 2009, 360(18):1870884. three. Kim A, Nicolau DP, Kuti JL: Hospital expenses and outcomes amongst intravenous antifungal therapies for patients with invasive Aspergillosis in the United states. Mycoses 2011, 54(5):e30112. 4. Wilson LS, Reyes CM, Stolpman M, Speckman J, Allen K, Beney J: The direct expense and incidence of Adding an Inhibitors medchemexpress systemic fungal infections. Worth Overall health 2002, five(1):264. five. Lin SJ, Schranz J, Teutsch SM: Aspergillosis case-fatality rate: systematic evaluation in the literature. Clin Infect Dis 2001, 32(three):35866. six. Feng X, Krishnan K, Richie DL, Aimanianda V, Hartl L, Grahl N, PowersFletcher MV, Zhang M, Fuller KK, Nierman WC, et al: HacA-independent functions of your ER anxiety sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS Pathog 2011, 7(ten):e1002330. 7. Richie DL, Hartl L, Aimanianda V, Winters MS, Fuller KK, Miley MD, White S, McCarthy JW, Latge JP, Feldmesser M, et al: A part for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus. PLoS Pathog 2009, five(1):e1000258. eight. Cheon SA, Jung KW, Chen YL, Heitman J, Bahn YS, Kang HA: Unique evolution from the UPR pathway with a novel bZIP transcription element, Hxl1, for controlling pathogenicity of Cryptococcus neoformans. PLoS Pathog 2011, 7(eight):e1002177. 9. Joubert A, Simoneau P, Campion C, Bataille-Simoneau N, Iacomi-Vasilescu B, Poupard P, Francois JM, Georgeault S, Sellier E, Guillemette T: Influence on the unfolded protein response around the pathogenicity from the Neurotrophic fungus Alternaria brassicicola. Mol Microbiol 2011, 79(5):1305324. 10. Miyazaki T, Nakayama H, Nagayoshi Y, Kakeya H, Kohno S: Dissection of Ire1 functions reveals strain response mechanisms uniquely evolved in Candida glabrata. PLoS Pathog 2013, 9(1):e1003160. 11. Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P: Endoplasmic reticulum anxiety sensing in the unfolded protein response. Cold Spring Harbor Perspect Biol 2013, 5(three):a013169. 12. Wimalasena TT, Enjalbert B, Guillemette T, Plumridge A, Budge S, Yin Z, Brown AJ, Archer DB: Influence in the unfolded protein response upon genome-wide expression patterns, plus the function of Hac1 in the polarized development, of Candida albicans. Fungal Genet Biol 2008, 45(9):1235247. 13. Hartmann T, Sasse C, Schedler A, Hasenbe.
