Ved because the superintendent on the Research Laboratory, Royal College of Physicians, Edinburgh. McKendrick to Cunningham, MedChemExpress ML240 December,, E., Papers and correspondence of John Cunningham,, reference code: GB Gen., boxes, Special Collections, Edinburgh University Library, Edinburgh (hereafter JC papers). “Further Note around the Antirabic Treatment Position,” LE,, APAC. “Notes on Literature on Rabies,” A., JC papers. Ether Experiments, I, Resistance to Ether, E., Ether Experiments, III. Human Instances Treated with Ether Virus,, Note, October, “It has been decided to treat the worst human instances attending the Institute with ether vaccine.” E., JC papers. Cunningham to Graham, copy to John K. S. Fleming, secretary, Pasteur 
Institute of India, January,, E., ibid.pratik chakrabartiCunningham’s preference for ether was as substantial as Semple’s decision of carbolic acid. The two attenuating agents had distinct historical trajectories. While carbolic acid was an antiseptic from Carlisle with a Listerian tradition, ether was an anesthetic with a Pasteurian lineage. It was origilly used by Pasteur for his rabies vaccine experiments after which by Remlinger and Roux. To Cunningham, ether seemed to possess a specific characteristic: “[T]reatment with ether removes the toxic substance, that is accountable for post therapy paralysis.” Quickly after he started, Cunningham received news of a suspicious death of a British subaltern med Norman following remedy with carbolized vaccine. His laboratory notes show reports of numerous additional individuals suffering from related postvaccil paralysis. This led him to express his doubts to Graham. He now wanted to start largescale experiments using the etherattenuated virus as well as centralization of vaccition in his laboratory in Kasauli. Cunningham was also suspicious of proof from the early success of carbolized vaccine in Indian institutes. He wrote to Graham that he couldn’t find any origil report of Semple’s experiments in Kasauli. Soon after looking in Shimla Graham found some confidential notes concerning the origil experiments of performed in Kasauli, which were, as he wrote to Cunningham, “extremely fascinating reading” and that “paralytic complications ensued from time to time.” Cunningham reported this to H. W. Acton (director on the Calcutta College of Tropical Medicine) and also the new proof 
with Semple’s vaccines that he had come across exactly where even percent carbolized vaccines PubMed ID:http://jpet.aspetjournals.org/content/125/4/309 triggered paralysis. He also wrote to Fleming (deputy DGIMS and secretary in the Pasteur Committee of India) challenging the policy of decentralization by using carbolized vaccines: “No 1 can claim, nonetheless, that carbolised vaccine.. would be the final word in antirabic treatment.” He pointed out that. The colorless, light, volatile liquid (CHO) resulting from the action of sulfuric acid upon alcohol. Lise Wilkinson, “The Development on the Virus Notion as Reflected in Corpora of Research on Individual Pathogens. Rabies��Two Millennia of Suggestions and Conjecture on the Aetiology of a Virus Disease,” Med. Hist. :, esp.. Cunningham to Graham, January,, E., JC papers. W. Keyworth to King, Mardan, March,, E., ibid.. Patient postcard towards the director, Pasteur Institute, Kasauli, January,, ibid. Cunningham to Graham, March,, ibid. Cunningham to Graham, August,, E., ibid. Graham, Workplace of DGIMS to Cunningham, September,, ibid. Cunningham to Acton, November,, ibid. Cunningham to Fleming, September,, ibid.The Pasteurian Paradigmrecent perform in Europe by Alivisatos, Hempt, and Busson w.Ved because the superintendent in the Investigation Laboratory, Royal College of Physicians, Edinburgh. McKendrick to Cunningham, December,, E., Papers and correspondence of John Cunningham,, reference code: GB Gen., boxes, Special Collections, Edinburgh University Library, Edinburgh (hereafter JC papers). “Further Note on the Antirabic Treatment Position,” LE,, APAC. “Notes on Literature on Rabies,” A., JC papers. Ether Experiments, I, Resistance to Ether, E., Ether Experiments, III. Human Cases Treated with Ether Virus,, Note, October, “It has been decided to treat the worst human situations attending the Institute with ether vaccine.” E., JC papers. Cunningham to Graham, copy to John K. S. Fleming, secretary, Pasteur Institute of India, January,, E., ibid.pratik chakrabartiCunningham’s preference for ether was as substantial as Semple’s option of carbolic acid. The two attenuating agents had distinct historical trajectories. When carbolic acid was an antiseptic from Carlisle having a Listerian tradition, ether was an anesthetic having a Pasteurian lineage. It was origilly applied by Pasteur for his rabies vaccine experiments after which by Remlinger and Roux. To Cunningham, ether seemed to possess a special characteristic: “[T]reatment with ether removes the toxic substance, which is accountable for post remedy paralysis.” Quickly following he began, Cunningham received news of a suspicious death of a British subaltern med Norman following therapy with carbolized vaccine. His laboratory notes show reports of various a lot more individuals affected by similar postvaccil paralysis. This led him to express his doubts to Graham. He now wanted to start largescale experiments using the etherattenuated virus and also centralization of vaccition in his laboratory in Kasauli. Cunningham was also suspicious of evidence in the early good results of carbolized vaccine in Indian institutes. He wrote to Graham that he could not find any origil report of Semple’s experiments in Kasauli. Following browsing in Shimla Graham discovered some confidential notes about the origil experiments of conducted in Kasauli, which had been, as he wrote to Cunningham, “extremely fascinating reading” and that “paralytic complications ensued from time to time.” Cunningham reported this to H. W. Acton (director with the Calcutta SMER28 School of Tropical Medicine) plus the new proof with Semple’s vaccines that he had encounter where even % carbolized vaccines PubMed ID:http://jpet.aspetjournals.org/content/125/4/309 brought on paralysis. He also wrote to Fleming (deputy DGIMS and secretary in the Pasteur Committee of India) difficult the policy of decentralization by utilizing carbolized vaccines: “No 1 can claim, nonetheless, that carbolised vaccine.. will be the final word in antirabic therapy.” He pointed out that. The colorless, light, volatile liquid (CHO) resulting in the action of sulfuric acid upon alcohol. Lise Wilkinson, “The Development in the Virus Concept as Reflected in Corpora of Studies on Individual Pathogens. Rabies��Two Millennia of Ideas and Conjecture around the Aetiology of a Virus Disease,” Med. Hist. :, esp.. Cunningham to Graham, January,, E., JC papers. W. Keyworth to King, Mardan, March,, E., ibid.. Patient postcard towards the director, Pasteur Institute, Kasauli, January,, ibid. Cunningham to Graham, March,, ibid. Cunningham to Graham, August,, E., ibid. Graham, Office of DGIMS to Cunningham, September,, ibid. Cunningham to Acton, November,, ibid. Cunningham to Fleming, September,, ibid.The Pasteurian Paradigmrecent perform in Europe by Alivisatos, Hempt, and Busson w.
