Verruculogen
Verruculogen is a mycotoxin initially produced by species of Aspergillus; it is considered a tremorgenic indole alkaloid and may induce development of neurological disorders. Verruculogen inhibits Ca2+-activated K+ (BK) channels and may also act as an antagonist on GABA-A receptors, binding at or near the Cl- channel.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18978790
| Cas No. |
12771-72-1 |
|---|---|
| Purity |
≥95% |
| Formula |
C27H33N3O7 |
| Formula Wt. |
511.57 |
| Melting Point |
230-233°C |
| Solubility |
DMSO, Methanol, Ethanol |
| Appearance |
White Powder |
Smith RC, McClure MC, Smith MA, et al. The role of voltage-gated potassium channels in the regulation of mouse uterine contractility. Reprod Biol Endocrinol. 2007 Nov 2;5:41. PMID: 17980032.
Kosalec I, Klarić MS, Pepeljnjak S. Verruculogen production in airborne and clinical isolates of Aspergillus fumigatus Fres. Acta Pharm. 2005 Dec;55(4):357-64. PMID: 16375825.
Knaus HG, McManus OB, Lee SH, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry. 1994 May 17;33(19):5819-28. PMID: 7514038.
Gant DB, Cole RJ, Valdes JJ, et al. Action of tremorgenic mycotoxins on GABAA receptor. Life Sci. 1987 Nov 9;41(19):2207-14. PMID: 2444852.
