Triptorelin
Triptorelin is a peptide analog of gonadotropin-releasing hormone (GnRH) that induces constant stimulation of the pituitary gland, decreasing release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Triptorelin exhibits anticancer and anxiolytic activities. Triptorelin inhibits cell proliferation in cellular models of breast cancer and ovarian cancer. This compound also increases open arm entries and social interaction time in animal models of anxiety.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18978355
| Cas No. |
57773-63-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C64H83N18O13 |
| Formula Wt. |
1311.5 |
| Chemical Name |
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycinamide |
| IUPAC Name |
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide |
| Synonym |
Decapeptyl; [DTrp6]-LH-RH, Amide |
| Appearance |
White to off white powder |
Saleh-Abady MM, Alizadeh A, Shamsipour F, et al. The anticancer activity compared between triptorelin and a new gonadotropin releasing hormone analogue. Avicenna J Med Biotechnol. 2009 Jul;1(2):105-10. PMID: 23407883.
Umathe SN, Bhutada PS, Jain NS, et al. Effects of central administration of gonadotropin-releasing hormone agonists and antagonist on elevated plus-maze and social interaction behavior in rats. Behav Pharmacol. 2008 Jul;19(4):308-16. PMID: 18622178.
