Triadimenol
Triadimenol is a metabolite of Triadimefon, a mutagenic antifungal compound used to manage fungal infections in agricultural crops. Like its parent compound, triadimenol may be neurotoxic, as it regulates retinoic acid levels and alters learning and memory function in vivo.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18978020
| Cas No. |
55219-65-3 |
|---|---|
| Purity |
≥96% |
| Formula |
C14H18ClN3O2 |
| Formula Wt. |
295.76 |
| Chemical Name |
β-(4-Chlorophenoxy)-α-(1,1-dimethylethyl)-1H-1,2,4- triazole-1-ethanol, (1RS, 2RS, 1RS, 2RS)-1-(4-Chlorohenoxy)-3,3-dimethyl-1-(1H-1,2,4 triazol-1-yl)butan-2-ol |
| IUPAC Name |
1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-ol |
| Synonym |
Bayfidan; Baytan; Spinnker; Summit |
| Melting Point |
112-117°C |
| Solubility |
Soluble in water (0.012 g/100 g), alcohol or ketones. |
| Appearance |
White Crystalline Powder |
Xi J, Yang Z, Zeng C, et al. Suppressive effect of triadimefon, a triazole fungicide, on spatial learning and reference memory in rats. Behav Pharmacol. 2012 Dec;23(8):727-34. PMID: 23080312.
Di Renzo F, Broccia ML, Giavini E, et al. Stage-dependent abnormalities induced by the fungicide triadimefon in the mouse. Reprod Toxicol. 2011 Feb;31(2):194-9. PMID: 21055463.
Berg D, Draber W, von Hugo H, et al. The effect of clotrimazole and triadimefon on 3-hydroxy-3-methyl-glutaryl-CoA-reductase-[EC 1.1.1.34]-activity in Saccharomyces cerevisiae. Z Naturforsch C. 1981 Sep-Oct;36(9-10):798-803. PMID: 7029940.
