Torsemide
Torsemide is a pyridine-sulfonyl urea loop diuretic known for its antihypertensive and cardioprotective activities. This compound acts as a competitive inhibitor of the Na+-K+-2Cl- symporter in the loop of Henle by binding directly to the Cl- binding site; this inhibition prevents reabsorption of Na+, Cl-, Mg2+, and Ca2+, resulting in a decrease in blood volume and pressure. Torsemide treats edema, hypertension, and congestive heart failure, attenuating left ventricular cardiac remodeling. This compound also inhibits aldosterone secretion and ATPase activity of HSP90.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18977439
| Cas No. |
56211-40-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C16H20N4O3S |
| Formula Wt. |
348.42 |
| Chemical Name |
N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide |
| IUPAC Name |
1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea |
| Synonym |
Torasemide |
| Appearance |
White to off white powder |
Sheikha GA, Al-Shaer MA, Taha MO. Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation. J Enzyme Inhib Med Chem. 2011 Oct;26(5):603-9. PMID: 21190426.
Kasama S, Toyama T, Hatori T, et al. Effects of torasemide on cardiac sympathetic nerve activity and left ventricular remodelling in patients with congestive heart failure. Heart. 2006 Oct;92(10):1434-40. PMID: 16621879.
Goodfriend TL, Ball DL, Oelkers W, et al. Torsemide inhibits aldosterone secretion in vitro. Life Sci. 1998;63(3):PL45-50. PMID: 9698054.
Lupinacci L, Puschett JB. An examination of the site and mechanism of action of torasemide in man. J Clin Pharmacol. 1988 May;28(5):441-7. PMID: 3392242.
Recasens M, Pin JP, Bockaert J. Chloride transport blockers inhibit the chloride-dependent glutamate binding to rat brain membranes. Neurosci Lett. 1987 Feb 24;74(2):211-6. PMID: 2883610.
