Terbutaline
Terbutaline is an agonist at β2-adrenergic receptors and is clinically used to treat asthma and cough. Terbutaline exhibits anti-tussive, anti-asthma, anti-allergic, tocolytic, and bronchodilatory activities. In vivo, terbutaline inhibits the production of TNF-α, improving pain/allodynia symptoms. In other animal models, terbutaline inhibits the cough response via modulation of cAMP and PKG signaling. Terbutaline also inhibits expression of corticotropin-releasing hormone in trophoblasts. In alveolar epithelial cells, this compound stimulates activity and increases expression of epithelial Na+ channels (ENaCs).
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18975657
| Cas No. |
23031-25-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C12H19NO3 |
| Formula Wt. |
225.28 |
| Chemical Name |
5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol |
| IUPAC Name |
5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol |
| Melting Point |
119-122°C |
| Appearance |
White to Off-White Cryatalline Powder |
Bohren Y, Tessier LH, Megat S, et al. Antidepressants suppress neuropathic pain by a peripheral β2-adrenoceptor mediated anti-TNFα mechanism. Neurobiol Dis. 2013 Dec;60:39-50. PMID: 23978467.
Freund-Michel VC, Birrell MA, Giembycz MA, et al. Beta(2)-agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway. Eur Respir J. 2010 Mar;35(3):647-54. PMID: 19679606.
Kontopoulos EV, Chandras C, Karalis K. Terbutaline inhibits corticotropin-releasing hormone (CRH) expression in human trophoblast cells. J Matern Fetal Neonatal Med. 2006 Nov;19(11):735-9. PMID: 17127497.
Planès C, Blot-Chabaud M, Matthay MA, et al. Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. J Biol Chem. 2002 Dec 6;277(49):47318-24. PMID: 12372821.
Johnson M. Beta2-adrenoceptors: mechanisms of action of beta2-agonists. Paediatr Respir Rev. 2001 Mar;2(1):57-62. PMID: 16263481.
Lui PW, Hsing CH, Chu YC. Terbutaline inhalation suppresses fentanyl-induced coughing. Can J Anaesth. 1996 Dec;43(12):1216-9. PMID: 8955969.
Koseki N, Deguchi J, Yamashita A, et al. Establishment fo a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish. J Toxicol Sci. 2014 Aug;39(4):579-600. PMID: 25056783.
