Tenovin-1
Tenovin-1 is an inhibitor of sirtuins 1 and 2 (SIRT1/2) that also indirectly activates p53; sirtuins are considered class III histone deacetylases (HDACs). Tenovin-1 exhibits anticancer potential, increasing FOXO3 and p53 expression and inducing apoptosis in cutaneous T-cell lymphoma cells.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18975343
| Cas No. |
380315-80-0 |
|---|---|
| Purity |
≥98% |
| Formula |
C20H23N3O2S |
| Formula Wt. |
369.48 |
| IUPAC Name |
N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide |
| Appearance |
White Crystal Powder |
Nihal M, Ahmad N, Wood GS. SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis. Cell Cycle. 2014 Feb 15;13(4):632-40. PMID: 24343700.
Lain S, Hollick JJ, Campbell J, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. PMID: 18455128.
