Teicoplanin
Teicoplanin is a glycopeptide antibiotic that displays antibacterial efficacy against gram positive bacteria. Teicoplanin is an analog of vancomycin with improved lipophilicity and bioavailability when given intramuscularly. Teicoplanin inhibits peptidoglycan formation and cell wall synthesis. This compound may also cause epileptogenic activity, potentially related to downstream modulation of GABA signaling. Teicoplanin is also used as a chiral selector in capillary liquid chromatography.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18975130
| Cas No. |
61036-62-2 |
|---|---|
| Purity |
≥900 ug/mg, bio assay |
| Formula |
C78H77Cl2N9O31 |
| Formula Wt. |
1707.39 |
| Chemical Name |
Ristomycin A 34-O-[2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(8-methyl-1-oxononyl)amino]-.beta.-D-glucopyranosyl]-42-O-.alpha.-D-mannopyranosyl- |
| Appearance |
White to light yellow powder |
Nailor MD, Sobel JD. Antibiotics for gram-positive bacterial infections: vancomycin, teicoplanin, quinupristin/dalfopristin, oxazolidinones, daptomycin, dalbavancin, and telavancin. Infect Dis Clin North Am. 2009 Dec;23(4):965-82, ix. PMID: 19909893.
Takechi K, Ishikawa T, Kamei C. Epileptogenic activity induced by teicoplanin and effects of some antiepileptics in mice. J Pharmacol Sci. 2008 Aug;107(4):428-33. PMID: 18678985.
Kafková B, Bosáková Z, Tesarová E, et al. Chiral separation of beta-adrenergic antagonists, profen non-steroidal anti-inflammatory drugs and chlorophenoxypropionic acid herbicides using teicoplanin as the chiral selector in capillary liquid chromatography. J Chromatogr A. 2005 Sep 23;1088(1-2):82-93. PMID: 16130735.
Somma S, Gastaldo L, Corti A. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. Antimicrob Agents Chemother. 1984 Dec;26(6):917-23. PMID: 6240963.
