Tazobactam
Tazobactam is a β-lactamase inhibitor that is clinically used to enhance the antibacterial efficacy of β-lactam antibiotics. Tazobactam is especially active against Enterobacter and Staphylococcus.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18974936
| Cas No. |
89786-04-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C10H12N4O5S |
| Formula Wt. |
300.29 |
| Chemical Name |
(2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2- carboxylic acid 4,4-dioxide |
| IUPAC Name |
(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Synonym |
YTR-830H; CL-298741 |
| Melting Point |
170-178°C |
| Solubility |
water, methanol |
| Appearance |
White Crystal Powder |
Zhanel GG, Chung P, Adam H, et al. Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli. Drugs. 2014 Jan;74(1):31-51. PMID: 24352909.
Frase H, Smith CA, Toth M, et al. Identification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry. J Biol Chem. 2011 Apr 22;286(16):14396-409. PMID: 21345789.
Drawz SM, Bonomo RA. Three decades of beta-lactamase inhibitors. Clin Microbiol Rev. 2010 Jan;23(1):160-201. PMID: 20065329.
