Sulfadiazine
Sulfadiazine is a sulfonamide antibiotic that inhibits folate production; it exhibits antibacterial activity.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18974052
| Cas No. |
68-35-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C10H10N4O2S |
| Formula Wt. |
250.28 |
| Chemical Name |
4-Amino-N-2-pyrimidinylbenzenesulfonamide |
| IUPAC Name |
4-amino-N-pyrimidin-2-ylbenzenesulfonamide |
| Synonym |
Adiazine; Diazyl; Sulfolex |
| Melting Point |
252-256°C |
| Solubility |
Insoluble in water. Sparingly soluble in alcohol or acetone. |
| Appearance |
White to off white powder |
Laue H, Weiss L, Bernardi A, et al. In vitro activity of the novel diaminopyrimidine, iclaprim, in combination with folate inhibitors and other antimicrobials with different mechanisms of action. J Antimicrob Chemother. 2007 Dec;60(6):1391-4. PMID: 17962215.
Richards RM, Xing JZ, Gregory DW, et al. Mechanism of sulphadiazine enhancement of trimethoprim activity against sulphadiazine-resistant Enterococcus faecalis. J Antimicrob Chemother. 1995 Oct;36(4):607-18. PMID: 8591935.
Ho YB, Zakaria MP, Latif PA, Saari N. Occurrence of veterinary antibiotics and progesterone in broiler manure and agricultural soil in Malaysia. Sci Total Environ. 2014 Aug 1;488-489:261-267. PMID: 24836135.
