SMI-4a
SMI-4a is a thiazolidine inhibitor of Pim kinase that displays anticancer chemotherapeutic activity. SMI-4a prevents phosphorylation of eIF4B and suppresses tumor growth in animal models of cancer. In myeloid and lymphoid cells, SMI-4a induces G1 phase cell cycle arrest, apoptosis, and cell death. Additionally, this compound delays tumor growth in animal models of precursor T-cell lymphoblastic leukemia/lymphoma.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18973502
| Cas No. |
438190-29-5 |
|---|---|
| Formula |
C11H6F3NO2S |
| Formula Wt. |
273.23 |
| IUPAC Name |
(5Z)-5-[3-(Trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione |
Yang J, Wang J, Chen K, et al. eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes. Cancer Res. 2013 Aug 1;73(15):4898-908. PMID: 23749639.
Lin YW, Beharry ZM, Hill EG, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 Jan 28;115(4):824-33. PMID: 19965690.
