Sedanolide
Sedanolide is a phthalide found in celery seeds that exhibits anti-inflammatory, antifungal, anti-parasitic, and nematocidal activities. Sedanolide inhibits COX-1 and COX-2 as well as topoisomerase I and topoisomerase II in vitro. Sedanolide displays antimicrobial efficacy against Aedes, Caenorhabditis, Candida, Drosophila, and Panagrellus.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18971819
| Cas No. |
6415-59-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C12H18O2 |
| Formula Wt. |
194.13 |
| Chemical Name |
3-Butyl-3α,4,5,6-tetrahydro-1(3H)-isobenzofuranone |
| IUPAC Name |
3-butyl-3a,4,5,6-tetrahydro-3H-2-benzofuran-1-one |
| Synonym |
Neocnidilide |
| Melting Point |
30-31°C |
| Solubility |
Soluble in acetonitrile, ethanol, and methanol. |
| Appearance |
White solid |
Tsukamoto T, Ishikawa Y, Miyazawa M. Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster. J Agric Food Chem. 2005 Jul 13;53(14):5549-53. PMID: 15998112.
Jiao XZ, Xie P, Zu LS, et al. Study of stereoselective synthesis of (+/-)-neocnidilide. J Asian Nat Prod Res. 2003 Sep;5(3):165-9. PMID: 12931848.
Momin RA, Nair MG. Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn. seeds. Phytomedicine. 2002 May;9(4):312-8. PMID: 12120812.
Momin RA, Nair MG. Mosquitocidal, nematicidal, and antifungal compounds from Apium graveolens L. seeds. J Agric Food Chem. 2001 Jan;49(1):142-5. PMID: 11305251.
