Se-Methylseleno-L-cysteine
Methylselenocysteine is found in plants in the Astragalus, Allium, and Brassica genera; it exhibits cytoprotective, chemopreventive, anti-angiogenic, antioxidative, and anti-inflammatory activities. Methylselenocysteine induces phase II enzyme activity and protects organs against chemotherapy-induced toxicity. In other models, methylselenocysteine increases expression of Nrf2, heme oxygenase 1 (HO-1), catalase, and glutathione-S-transferase, protecting against radiation-induced oxidative damage. Additionally, this compound decreases activation of NF-κB, p38 MAPK, and JNK and decreases expression of iNOS in LPS-stimulated macrophages.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18971526
| Cas No. |
26046-90-2 |
|---|---|
| Purity |
≥98% |
| Formula |
C4H9NO2Se |
| Formula Wt. |
182.08 |
| Chemical Name |
3-(methylseleno)-L-alanine |
| IUPAC Name |
(2R)-2-amino-3-methylselanylpropanoic acid |
| Synonym |
Methylselenocysteine; Selenium-methylselenocystine; 2-Amino-3-methylselenyl propionic acid |
| Appearance |
White to off white powder |
Cao S, Durrani FA, Tóth K, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43. PMID: 24619073.
Shin HS, Yang WJ, Choi EM. The preventive effect of Se-methylselenocysteine on γ-radiation-induced oxidative stress in rat lungs. J Trace Elem Med Biol. 2013 Apr;27(2):154-9. PMID: 23176811.
Bhattacharya A. Methylselenocysteine: a promising antiangiogenic agent for overcoming drug delivery barriers in solid malignancies for therapeutic synergy with anticancer drugs. Expert Opin Drug Deliv. 2011 Jun;8(6):749-63. PMID: 21473705.
Pan MH, Hong HM, Lin CL, et al. Se-methylselenocysteine inhibits lipopolysaccharide-induced NF-κB activation and iNOS induction in RAW 264.7 murine macrophages. Mol Nutr Food Res. 2011 May;55(5):723-32. PMID: 21213327.
Zhang J, Wang L, Anderson LB, et al. Proteomic profiling of potential molecular targets of methyl-selenium compounds in the transgenic adenocarcinoma of mouse prostate model. Cancer Prev Res (Phila). 2010 Aug;3(8):994-1006. PMID: 20647336.
