Ranatensin
Ranatensin is a peptide originally found in amphibian skin that exhibits gastrointestinal motility modulating activity. Ranatensin stimulates Cl- secretion in the jejunum in a GRP-related manner. Ranatensin also stimulates secretion of gastrin, pancreatic polypeptide, and gastric acid in animal models.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18957447
| Cas No. |
29451-71-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C61H85N16O13S |
| Formula Wt. |
1281.5 |
| Chemical Name |
Pyroglutamyl-valyl-prolyl-glutaminyl-tryptophyl-alanyl-valyl-glycyl-histidyl-phenylalanyl-methionylamide |
| IUPAC Name |
N-[1-[[1-[[1-[[2-[[1-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[1-[3-methyl-2-[(5-oxopyrrolidine-2-carbonyl)amino]butanoyl]pyrrolidine-2-carbonyl]amino]pentanediamide |
| Solubility |
Soluble in water. |
Chandan R, Newell SM, Brown DR. Actions of gastrin-releasing peptide and related mammalian and amphibian peptides on ion transport in the porcine proximal jejunum. Regul Pept. 1988 Oct;23(1):1-14. Erratum in: Regul Pept 1989 Mar;24(3):312. PMID: 3238049.
Modlin IM, Lamers CB, Walsh JH. Stimulation of canine pancreatic polypeptide, gastrin, and gastric acid secretion by ranatensin, litorin, bombesin nonapeptide and substance P. Regul Pept. 1981 Jan;1(4):279-88. PMID: 6166964.
