Psoralen
Psoralen is a furanocoumarin compound originally found in Psoralea coryfolia that exhibits anti-angiogenic activity. Psoralen is currently used to treat psoriasis with the additional of UVA light. Psoralen inhibits angiogenesis and induces G0/G1 phase cell cycle arrest and apoptosis in endothelial cells. This compound also inhibits topoisomerase I and induces DNA interstrand crosslinks and monoadducts, displaying carcinogenic potential as well.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18955439
| Cas No. |
66-97-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C11H6O3 |
| Formula Wt. |
186.16 |
| IUPAC Name |
furo[3,2-g]chromen-7-one |
| Synonym |
Ficusin |
| Melting Point |
163-164°C |
| Solubility |
Soluble in ethanol (10 mg/ml), ethyl acetate, acetone, and water (1.93 mg/ml at 25 °C). |
| Appearance |
White Crystal Powder |
Chopra B, Dhingra AK, Dhar KL. Psoralea corylifolia L. (Buguchi) – folklore to modern evidence: review. Fitoterapia. 2013 Oct;90:44-56. PMID: 23831482.
Diwan R, Malpathak N. Furanocoumarins: novel topoisomerase I inhibitors from Ruta graveolens L. Bioorg Med Chem. 2009 Oct 1;17(19):7052-5. PMID: 19736019.
Derheimer FA, Hicks JK, Paulsen MT, et al. Psoralen-induced DNA interstrand cross-links block transcription and induce p53 in an ataxia-telangiectasia and rad3-related-dependent manner. Mol Pharmacol. 2009 Mar;75(3):599-607. PMID: 19064630.
Deng H, Yan CL, Hu Y, et al. Photochemotherapy inhibits angiogenesis and induces apoptosis of endothelial cells in vitro. Photodermatol Photoimmunol Photomed. 2004 Aug;20(4):191-9. PMID: 15238097.
