Polydatin
Polydatin is a resveratrol-related glucoside originally found in Polygonum cuspidatum. Polydatin exhibits anticancer, anti-inflammatory, antioxidative, and anti-allergic activities. In lung cancer cells, polydatin downregulates expression of cyclin D1 and Bcl-2 and upregulates expression of Bax, inducing cell cycle arrest and apoptosis. In animal models of sepsis, polydatin decreases sepsis-induced mortality and lung injury by suppressing production of COX-2, iNOS, and inflammatory cytokines. Polydatin also decreases the loss of mucosal barrier integrity in the small intestine due to OVA-induced allergy by inhibiting mast cell degranulation.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18955315
| Cas No. |
65914-17-2 |
|---|---|
| Purity |
≥97% |
| Formula |
C20H22O8 |
| Formula Wt. |
390.38 |
| Chemical Name |
3-Hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl-beta-D-glucoside |
| IUPAC Name |
(2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
| Synonym |
Resveratrol 3-β-mono-D-glucoside |
| Melting Point |
223-226°C |
| Solubility |
Soluble in methanol, ethanol acetone, hot water or ethyl acetate. |
| Appearance |
White powder |
Zhang Y, Zhuang Z, Meng Q, et al. Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest. Oncol Lett. 2014 Jan;7(1):295-301. PMID: 24348867.
Yang B, Li JJ, Cao JJ, et al. Polydatin attenuated food allergy via store-operated calcium channels in mast cell. World J Gastroenterol. 2013 Jul 7;19(25):3980-9. PMID: 23840142.
Li XH, Gong X, Zhang L, et al. Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1. Mediators Inflamm. 2013;2013:354087. PMID: 23431240.
Wu MJ, Gong X, Jiang R, et al. Polydatin protects against lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice. Int J Immunopathol Pharmacol. 2012 Oct-Dec;25(4):923-34. PMID: 23298483.
