Pirfenidone
Pirfenidone is an anti-fibrotic and anti-inflammatory compound that is used to treat pulmonary fibrosis. Pirfenidone decreases fibroblast production, suppresses expression of TNF-α and IL-1β, and inhibits TGF-β-induced stimulation of collagen production. In vivo, this compound prevents the development of pulmonary fibrosis.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18954711
| Cas No. |
53179-13-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C12H11NO |
| Formula Wt. |
185.22 |
| IUPAC Name |
5-Methyl-1-phenyl-2(1H)-pyridinone |
| Appearance |
Pale yellow to off white powder |
Xiang XH, Jiang TP, Zhang S, et al. Pirfenidone inhibits proliferation, arrests the cell cycle, and downregulates heat shock protein 47 and collagen type I in rat hepatic stellate cells in vitro. Mol Med Rep. 2015 Mar 3. [Epub ahead of print]. PMID: 25738437.
Cottin V, Maher T. Long-term clinical and real-world experience with pirfenidone in the treatment of idiopathic pulmonary fibrosis. Eur Respir Rev. 2015 Mar;24(135):58-64. PMID: 25726556.
Iyer SN, Wild JS, Schiedt MJ, et al. Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters. J Lab Clin Med. 1995 Jun;125(6):779-85. PMID: 7539478.
