Piperacillin
Piperacillin is a β-lactam antibiotic that inhibits bacterial cell wall synthesis. Piperacillin is often paired with a β-lactamase inhibitor such as Tazobactam, improving its antibacterial efficacy.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1895456
| Cas No. |
61477-96-1 |
|---|---|
| Purity |
≥95% |
| Formula |
C23H27N5O7S |
| Formula Wt. |
517.56 |
| Chemical Name |
[[2S-[2α,5α,6β(S*)]]-6-[[[[(4-ethyl-2,3-dioxo-1- piperazinyl)carbonyl]amino]-phenylacetyl]amino]-3,3- dimethyl-7-oxo-4-Thia-1-azabicyclo[3.2.0]heptane-2- carboxylic acid |
| IUPAC Name |
(2S,5R,6R)-6-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Synonym |
CCRIS 7362; EINECS 262-811-8 |
| Solubility |
Soluble in water. |
| Appearance |
White Crystal Powder |
Fernández-Canigia L, Litterio M, Legaria MC, et al. First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina. Antimicrob Agents Chemother. 2012 Mar;56(3):1309-14. PMID: 22232282.
Bonfiglio G, Laksai Y, Franceschini N, et al. In vitro activity of piperacillin/tazobactam against 615 Pseudomonas aeruginosa strains isolated in intensive care units. Chemotherapy. 1998 Sep-Oct;44(5):305-12. PMID: 9732144.
Kadima TA, Weiner JH. Mechanism of suppression of piperacillin resistance in enterobacteria by tazobactam. Antimicrob Agents Chemother. 1997 Oct;41(10):2177-83. PMID: 9333044.
