Physalaemin
Physalaemin is an amphibian tachykinin neuropeptide. This peptide induces contractions in distal colon and esophageal longitudinal muscle in vivo through direct activation of smooth muscle cells and Ca2+ influx.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18954143
| Cas No. |
2507-24-6 |
|---|---|
| Purity |
≥95% |
| Formula |
C58H84N14O16S |
| Formula Wt. |
1265.48 |
| IUPAC Name |
4-[2-[[4-amino-1-[[6-amino-1-[[1-[[1-[[2-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-oxo-3-[2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoylamino]butanoic acid |
Shiina T, Shima T, Hirayama H, et al. Contractile responses induced by physalaemin, an analogue of substance P, in the rat esophagus. Eur J Pharmacol. 2010 Feb 25;628(1-3):202-6. PMID: 19958761.
Fontaine J, Lebrun P. Contractile effects of substance P and other tachykinins on the mouse isolated distal colon. Br J Pharmacol. 1989 Mar;96(3):583-90. PMID: 2470454.
