Phyllomedusin
Phyllomedusin is an amphibian tachykinin neuropeptide that activates neurokinin 1 (NK1) receptors. Phyllomedusin induces contractions in ileal longitudinal muscle and stimulates spasmogenic activity in stomach smooth muscle.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18954125
| Cas No. |
26145-48-2 |
|---|---|
| Purity |
≥95% |
| Formula |
C52H82N16O13S |
| Formula Wt. |
1171.41 |
| IUPAC Name |
N-[1-[[1-[[1-[[2-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[1-[4-amino-4-oxo-2-[(5-oxopyrrolidine-2-carbonyl)amino]butanoyl]pyrrolidine-2-carbonyl]amino]butanediamide |
Ganjiwale AD, Cowsik SM. Three-dimensional structure of Phyllomedusin, a NK1 receptor agonist bound to dodecylphosphocholine micelles. J Struct Biol. 2009 Aug;167(2):176-84. PMID: 19409496.
Bertaccini G, Coruzzi G. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163-6. PMID: 882154.
Széli J, Molina E, Zappia L, et al. Action of some natural polypeptides on the longitudinal muscle of the guinea pig ileum. Eur J Pharmacol. 1977 Jun 1;43(3):285-7. PMID: 872882.
