Pantoprazole
Pantoprazole is an H+/K+ ATPase inhibitor that exhibits antacid, anti-parasitic, and anticancer chemotherapeutic activities. Pantoprazole is clinically used to treat gastroesophageal reflux disease (GERD), although its inhibition of ROCK-2 causes a decrease in gastroesophageal sphincter muscle tone. In Trichomonas, pantoprazole inhibits uridine nucleoside ribohydrolase activity. Additionally, pantoprazole increases tumor-associated macrophage recruitment in the tumor microenvironment, inhibiting tumor growth in vivo.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18952752
| Cas No. |
102625-70-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C16H15F2N3O4S |
| Formula Wt. |
383.37 |
| Chemical Name |
5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)- methyl]sulfinyl]-1H-benzimidazole |
| IUPAC Name |
6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole |
| Synonym |
SKF-96022; BY-1023 |
| Melting Point |
139-140°C (dec) |
| Solubility |
Soluble in methanol. Soluble in water (48 mg/ml). |
| Appearance |
Off-White Crystal Powder |
Welsh C, Kasirer MY, Pan J, et al. Pantoprazole decreases gastroesophageal muscle tone in newborn rats via rho-kinase inhibition. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 3. [Epub ahead of print]. PMID: 24699328.
Shea TA, Burburan PJ, Matubia VN, et al. Identification of proton-pump inhibitor drugs that inhibit Trichomonas vaginalis uridine nucleoside ribohydrolase. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1080-4. PMID: 24468412.
Ward RM, Kearns GL. Proton pump inhibitors in pediatrics : mechanism of action, pharmacokinetics, pharmacogenetics, and pharmacodynamics. Paediatr Drugs. 2013 Apr;15(2):119-31. PMID: 23512128.
Vishvakarma NK, Singh SM. Immunopotentiating effect of proton pump inhibitor pantoprazole in a lymphoma-bearing murine host: Implication in antitumor activation of tumor-associated macrophages. Immunol Lett. 2010 Nov 30;134(1):83-92. PMID: 20837061.
