p-Xyleneselenocyanate
p-Xyleneselenocyanate is a synthetic derivative of selenocyanate. Derivatives of selenocyanate exhibit antioxidative, anticancer, and anti-parasitic activities.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18952135
| Cas No. |
85539-83-9 |
|---|---|
| Purity |
≥99% |
| Formula |
C10H8N2Se2 |
| Formula Wt. |
314.10 |
| Chemical Name |
1,4-Phenylenebis(methylene)selenocyanate |
| IUPAC Name |
2-methylsulfanylethylurea |
| Synonym |
p-XSC |
| Melting Point |
156°C |
| Solubility |
Soluble in DMSO. |
| Appearance |
White Crystalline Powder |
Das JK, Sarkar S, Hossain SU, et al. Diphenylmethyl selenocyanate attenuates malachite green induced oxidative injury through antioxidation & inhibition of DNA damage in mice. Indian J Med Res. 2013 Jun;137(6):1163-73. PMID: 23852297.
Facompre ND, Sinha I, El-Bayoumy K, et al. Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells. Int J Cancer. 2012 Nov 1;131(9):2134-42. PMID: 22307455.
Plano D, Baquedano Y, Moreno-Mateos D, et al. Selenocyanates and diselenides: a new class of potent antileishmanial agents. Eur J Med Chem. 2011 Aug;46(8):3315-23. PMID: 21571403.
Poerschke RL, Moos PJ. Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction. Biochem Pharmacol. 2011 Jan 15;81(2):211-221. PMID: 20920480.
