Nocodazole
Nocodazole is an inhibitor of microtubule polymerization that exhibits anticancer and anti-parasitic activities. Nocodazole induces depolarization of the mitochondrial membrane, caspase activation, PARP cleavage, and apoptosis in chronic lymphocytic leukemia (CLL) cells. Nocodazole also kills Alveococcus larvocysts in vivo.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18949596
| Cas No. |
31430-18-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C14H11N3O3S |
| Formula Wt. |
301.32 |
| Chemical Name |
[5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]- carbamic acid methyl ester |
| IUPAC Name |
methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate |
| Synonym |
Oncodazole; R 17934 |
| Melting Point |
300°C (dec) |
| Solubility |
Soluble in DMSO. Insoluble in water. |
| Appearance |
Off-white powder |
Shkoliar NA, Kukhaleva IV, Legonkov IuA, et al. Study of the therapeutic activity of nocodazole on experimental models of larval alveococcosis. Med Parazitol (Mosk). 2013 Apr-Jun;(2):20-7. PMID: 24003517.
Beswick RW, Ambrose HE, Wagner SD. Nocodazole, a microtubule de-polymerising agent, induces apoptosis of chronic lymphocytic leukaemia cells associated with changes in Bcl-2 phosphorylation and expression. Leuk Res. 2006 Apr;30(4):427-36. PMID: 16162358.
Rahajeng J, Giridharan SS, Naslavsky N, Caplan S. Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors. J Biol Chem. 2010 Oct 15;285(42):31918-31922. PMID: 20801876.
