Nociceptin
Nociceptin is an endogenous neuropeptide that binds the nociceptin (NOP) receptor, considered the ‘fourth’ opioid receptor subtype. Nociceptin displays anti-opioid activity, modulating nociception and exhibiting anti-analgesic properties in vivo. In the amygdala, nociceptin displays neuromodulatory activity, decreasing glutamate release. Additionally, nociceptin inhibits the activity of POMC neurons and modulates GIRK channel signaling, altering animal mating behavior.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18949576
| Cas No. |
170713-75-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C79H129N27O22 |
| Formula Wt. |
1809.1 |
| Chemical Name |
Orphanin FQ |
| Solubility |
Soluble in water. |
Borgquist A, Rivas VM, Kachani M, et al. Gonadal Steroids Differentially Modulate the Actions of Orphanin FQ/Nociceptin at A Physiologically Relevant Circuit Controlling Female Sexual Receptivity. J Neuroendocrinol. 2014 May;26(5):329-40. PMID: 24617903.
Kallupi M, Varodayan FP, Oleata CS, et al. Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Neuropsychopharmacology. 2014 Apr;39(5):1081-92. PMID: 24169802.
Okuda-Ashitaka E, Minami T, Tachibana S, et al. Nocistatin, a peptide that blocks nociceptin action in pain transmission. Nature. 1998 Mar 19;392(6673):286-9. PMID: 9521323.
