NMS-873
NMS-873 inhibits valosin-containing protein (VCP; p97/Cdc48p), an ATPase involved in endoplasmic reticulum-associated degradation. NMS-873 displays anticancer activity, activating the unfolded protein response, interfering with autophagy, and inducing cell death in cancer cells.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18949395
| Cas No. |
1418013-75-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C27H28N4O3S2 |
| Formula Wt. |
520.67 |
| IUPAC Name |
3-[3-(Cyclopentylsulfanyl)-5-({[2-methyl-4-(methylsulfonyl)-4-biphenylyl]oxy}methyl)-4H-1,2,4-triazol-4-yl]pyridine |
| Synonym |
NMS873 |
Chou TF, Bulfer SL, Weihl CC, et al. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol. 2014 Jul 29;426(15):2886-99. PMID: 24878061.
Magnaghi P, DAlessio R, Valsasina B, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56. PMID: 23892893.
