Nicotinamide
Nicotinamide is an amide form of vitamin B3 that is incorporated into NAD and NADP as oxidation-reduction coenzymes. Nicotinamide exhibits anti-inflammatory and anxiolytic activities; it is clinically used to treat acne vulgaris and rosacea. Commercially, nicotinamide is used in skin whitening treatments as it decreases skin pigmentation. Nicotinamide also binds GABA receptors, decreasing aggressive behavior.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18948668
| Cas No. |
98-92-0 |
|---|---|
| Purity |
≥98% |
| Formula |
C6H6N2O |
| Formula Wt. |
122.12 |
| Chemical Name |
3-Pyridinecarboxylic acid amide |
| IUPAC Name |
pyridine-3-carboxamide |
| Synonym |
Niacinamide; Nicotinic acid amide; Pyridine-3-carboxylic acid amide; Vitamin PP; Vitamin B3 |
| Melting Point |
128-131°C |
| Solubility |
Soluble in water (>600 mg/mL), ethanol (180 mg/mL), or glycerol. Insoluble in ether or acetone. |
| Appearance |
White Crystal Powder |
Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, et al. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatol Res Pract. 2011;2011:379173. PMID: 21822427.
Niren NM. Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review. Cutis. 2006 Jan;77(1 Suppl):11-6. PMID: 16871774.
Akhundov RA, Sultanov AA, Gadzhily RA, et al. Psychoregulating role of nicotinamide. Biull Eksp Biol Med. 1993 May;115(5):487-91. PMID: 7913840.
Paul SM, Marangos PJ, Skolnick P, et al. Biological substrates of anxiety: benzodiazepine receptors and endogenous ligands. Encephale. 1982;8(2):131-44. PMID: 6125374.
