Nicardipine
Nicardipine is a dihydropyridine L-type Ca2+ channel blocker that displays antihypertensive, vasodilatory, and antinociceptive activities. In animal models, it also displays neuromodulatory and cognition enhancing activities, inhibiting amygdala kindling and enhancing GABA signaling. Separately, it increases the pain threshold during tests of mechanical pain and prevents hypoxia-induced memory impairment.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18948652
| Cas No. |
55985-32-5 |
|---|---|
| Purity |
≥98% |
| Formula |
C26H29N3O6 |
| Formula Wt. |
479.52 |
| IUPAC Name |
5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Appearance |
White to off white powder |
Yue W, Wang L, Zhang F, et al. Inhibition of nicardipine on amygdala kindling in rats. Acta Pharmacol Sin. 2001 Apr;22(4):365-8. PMID: 11742591.
Eraković V, Zupan G, Mrsić J, et al. The influence of nicardipine and ifenprodil on the brain free arachidonic acid level and behavior in hypoxia-exposed rats. Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):633-47. PMID: 9194145.
Mashimo T, Pak M, Choe H, et al. Effects of vasodilators guanethidine, nicardipine, nitroglycerin, and prostaglandin E1 on primary afferent nociceptors in humans. J Clin Pharmacol. 1997 Apr;37(4):330-5. PMID: 9115059.
Kanneganti M, Halpern NA. Acute hypertension and calcium-channel blockers. New Horiz. 1996 Feb;4(1):19-25. PMID: 8689271.
