Neuromedin
Neuromedin N is an endogenous proneurotensin peptide involved in energy homeostasis regulation; it modulates hypothalamic thermoregulatory signaling in animal models and induces contraction in ileal smooth muscle cells. Neuromedin N also inhibits reward/reinforcement signaling by inhibiting the intracranial self-stimulation (ICSS) in animal models of reward and reinforcement. Src activates proneurotensin/neuromedin N promoter activity in a Raf-dependent manner. Additionally, neuromedin N is inactivated by dipeptidyl peptidases and aminopeptidases.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18948289
| Cas No. |
102577-25-3 |
|---|---|
| Purity |
≥95% |
| Formula |
C38H63N7O8 |
| Formula Wt. |
745.97 |
| IUPAC Name |
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid |
| Synonym |
Neuromedin N |
Basir YJ, Knoop FC, Dulka J, et al. Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris. Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. PMID: 11087945.
Banker NA, Hellmich MR, Kim HJ, et al. Src-mediated activation of the human neurotensin/neuromedin N promoter. Surgery. 1997 Aug;122(2):180-6. PMID: 9288121.
Fernández R, Alba F, Ferrer JM. Peptidase inhibitors potentiate the effects of neurotensin and neuromedin N on self-stimulation of the medial prefrontal cortex. Neuroreport. 1996 Feb 29;7(3):798-800. PMID: 8733748.
Barelli H, Woskowska Z, Cipris S, et al. Pharmacological role and degradation processes of neuromedin N in the gastrointestinal tract: an in vitro and in vivo study. J Pharmacol Exp Ther. 1995 Dec;275(3):1300-7. PMID: 8531096.
Malendowicz LK, Nussdorfer GG, Markowska A, et al. Investigations on the acute effects of neuropeptides on the pituitary-adrenocortical function in normal and cold-stressed rats. II. Neurotensin and neuromedin N. Exp Toxicol Pathol. 1995 Jan;47(1):41-5. PMID: 7719120.
