Naltriben
Naltriben is an antagonist at δ2-opioid receptors (D2ORs). Naltriben induces anxiety in animal models undergoing light/dark tests and open field activity measurements; it also inhibits opioid-induced reinforcement in conditioned place preference assays. Additionally, naltriben inhibits antinociceptive activities regulated by δORs in the spinal cord.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18947966
| Purity |
≥95% |
|---|---|
| Formula |
C50H65N11O11S2 |
| Formula Wt. |
1060.29 |
| Synonym |
NTB |
Sugiyama A, Nagase H, Oka JI, et al. DOR2-selective but not DOR1-selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology. 2013 Dec 12;79C:314-320. PMID: 24333676.
Billa SK, Xia Y, Morón JA. Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse. Eur J Neurosci. 2010 Aug;32(4):625-31. PMID: 20626460.
Tseng LF, Collins KA, Portoghese PS. Spinal delta 2 but not delta 1 opioid receptors are involved in intracerebroventricular beta-endorphin-induced antinociception in the mouse. Life Sci. 1993;52(19):PL211-5. PMID: 8387138.
