n-Octyl-3,4-Dimethylcaffeate
This product is a methylated derivative of n-octyl-caffeate. n-Octyl caffeate exhibits antioxidative, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities. n-Octyl caffeate decreases lipid peroxidation, activity of xanthine oxidase, activation of JNK and ERK, and production of NO and iNOS in rat brain homogenate; it also prevents the LPS-induced drop in mean arterial pressure in aortic smooth muscle cells. In animal models of tumor metastasis, n-octyl caffeate decreases tumor nodules.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18947210
| Purity |
≥98% |
|---|---|
| Formula |
C19H28O4 |
| Formula Wt. |
320.42 |
| Synonym |
3,4-Dimethylcaffeic acid n-octyl ester; 3,4-dimethoxycinnamic acid n-octyl ester |
| Appearance |
White Powder |
Nagaoka T, Banskota AH, Tezuka Y, et al. Inhibitory effects of caffeic acid phenethyl ester analogues on experimental lung metastasis of murine colon 26-L5 carcinoma cells. Biol Pharm Bull. 2003 May;26(5):638-41. PMID: 12736504.
Hsiao G, Shen MY, Chang WC, et al. A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells. Biochem Pharmacol. 2003 Apr 15;65(8):1383-92. PMID: 12694879.
