N-formyl-Met-Leu-Phe
N-fMLF is a peptide that binds n-formyl peptide receptors (FPRs) on neutrophils, playing a role in neutrophil activation. This peptide activates NADPH oxidase-dependent respiratory burst in neutrophils, generating ROS and inflammatory signaling cascades.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18946667
| Cas No. |
59880-97-6 |
|---|---|
| Purity |
≥95% |
| Formula |
C21H31N3O5S |
| Formula Wt. |
437.6 |
| IUPAC Name |
2-[[2-[(2-formamido-4-methylsulfanylbutanoyl)amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid |
| Synonym |
N-Formylmethionine leucyl-phenylalanine; L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)-; Tyramine HCl; N-Formyl-Met-Leu-Phe |
| Appearance |
White to off white powder |
Hurtado-Nedelec M, Makni-Maalej K, Gougerot-Pocidalo MA, et al. Assessment of priming of the human neutrophil respiratory burst. Methods Mol Biol. 2014;1124:405-12. PMID: 24504964.
Andréasson E, Önnheim K, Forsman H. The subcellular localization of the receptor for platelet-activating factor in neutrophils affects signaling and activation characteristics. Clin Dev Immunol. 2013;2013:456407. PMID: 24069041.
Sengeløv H, Boulay F, Kjeldsen L, et al. Subcellular localization and translocation of the receptor for N-formylmethionyl-leucyl-phenylalanine in human neutrophils. Biochem J. 1994 Apr 15;299 ( Pt 2):473-9. PMID: 8172608.
