N-Acetyl-D-Leucine
N-acetyl-D-leucine is a D-amino acid that is deacylated in bacteria by d-aminoacylase enzymes. D-amino acids inhibit bacterial biofilm formation when they are incorporated into the cell wall. Compounds such as N-acetyl-D-leucine induce release of amyloid fibers that link cells together in the biofilm.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18946351
| Cas No. |
19764-30-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C8H15NO3 |
| Formula Wt. |
173.21 |
| IUPAC Name |
(2R)-2-acetamido-4-methylpentanoic acid |
| Melting Point |
176-177°C |
| Appearance |
White to off white crystalline powder |
Leiman SA, May JM, Lebar MD, et al. D-amino acids indirectly inhibit biofilm formation in Bacillus subtilis by interfering with protein synthesis. J Bacteriol. 2013 Dec;195(23):5391-5. PMID: 24097941.
Kolodkin-Gal I, Romero D, Cao S, et al. D-amino acids trigger biofilm disassembly. Science. 2010 Apr 30;328(5978):627-9. PMID: 20431016.
Cummings JA, Fedorov AA, Xu C, et al. Annotating enzymes of uncertain function: the deacylation of D-amino acids by members of the amidohydrolase superfamily. Biochemistry. 2009 Jul 14;48(27):6469-81. PMID: 19518059.
