N-(4-Carbethoxyphenyl)retinamide
N-(4-Carbethoxyphenyl)retinamide is a retinoid that exhibits anticancer chemotherapeutic and chemopreventive activities. This compound inhibits development of stomach and oral cancers in vivo and shows some benefit in the treatment of dysplasias. Additionally, this compound induces differentiation in leukemia cells.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18946196
| Cas No. |
53839-71-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C29H37NO3 |
| Formula Wt. |
447.62 |
| IUPAC Name |
ethyl4-[[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl]amino]benzoate |
| Synonym |
4-(Ethoxycarbophenyl)retinamide; N-(Carbo- ethoxyphenyl)retinamide |
| Melting Point |
174-179°C |
| Solubility |
Soluble in DMSO or ethanol. |
| Appearance |
Yellow Powder |
Han J. Highlights of the cancer chemoprevention studies in China. Prev Med. 1993 Sep;22(5):712-22. PMID: 8234211.
Song ZP, Liu YH, Han R. Differentiation of human promyelocytic leukemia (HL-60) cells induced by new synthetic retinoids 4-(ethoxycarbophenyl) retinamide and 4-(hydroxycarbophenyl) retinamide. Yao Xue Xue Bao. 1984 Aug;19(8):576-81. PMID: 6399190.
