Myomodulin
Myomodulin is a neuromodulatory peptide found in molluscs, insects, and gastropods. In leeches, myomodulin inhibits activity of the Na+/K+ pump, increasing hyperpolarization-activated current I(h) and altering heart neuron spike and burst frequency. In glial cell membranes, myomodulin evokes membrane outward currents and elicits increases in K+ conductance. Across many cellular models, myomodulin modulates K+, Na+, and Ca2+ current amplitudes. Additionally, myomodulin increases muscle contraction frequency, increasing gut motility.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18946066
| Cas No. |
110570-93-9 |
|---|---|
| Purity |
≥95% |
| Formula |
C36H67N11O8S2 |
| Formula Wt. |
846.13 |
| IUPAC Name |
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]pyrrolidine-2-carboxamide |
| Synonym |
Myomodulin A , Myomoduline A |
| Appearance |
White to off white powder |
Tobin AE, Calabrese RL. Myomodulin increases Ih and inhibits the NA/K pump to modulate bursting in leech heart interneurons. J Neurophysiol. 2005 Dec;94(6):3938-50. PMID: 16093342.
Britz FC, Deitmer JW. Membrane responses of the leech giant glial cell to the peptide transmitter myomodulin. Peptides. 2002 Dec;23(12):2117-25. PMID: 12535690.
Wang Y, Strong JA, Sahley CL. Modulatory effects of myomodulin on the excitability and membrane currents in Retzius cells of the leech. J Neurophysiol. 1999 Jul;82(1):216-25. PMID: 10400950.
Perry SJ, Straub VA, Kemenes G, et al. Neural modulation of gut motility by myomodulin peptides and acetylcholine in the snail Lymnaea. J Neurophysiol. 1998 May;79(5):2460-74. PMID: 9582220.
