MS436
MS346 is an inhibitor of bromodomain BRD4. This compound displays anti-inflammatory activity, decreasing the production of NO and pro-inflammatory cytokines in macrophages.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18945969
| Cas No. |
1395084-25-9 |
|---|---|
| Formula |
C18H17N5O3S |
| Formula Wt. |
383.43 |
| IUPAC Name |
4-[(E)-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(2-pyridinyl)benzenesulfonamide |
Zhang G, Plotnikov AN, Rusinova E, et al. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64. PMID: 24144283.
