Molsidomine
Molsidomine is a NO donor that exhibits vasodilatory, cardioprotective, anti-atherosclerotic, and anticoagulant activities. Molsidomine inhibits PDGF-induced smooth muscle cell migration and proliferation and suppresses carotid artery neointima formation in vivo by inhibiting activity of annexin A2. In vitro, molsidomine inhibits activated platelet adhesion.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18945769
| Cas No. |
25717-80-0 |
|---|---|
| Purity |
≥98% |
| Formula |
C9H14N4O4 |
| Formula Wt. |
242.23 |
| Chemical Name |
N-(Ethoxycarbonyl)-3-(4-morpholinyl)sydnone imine |
| IUPAC Name |
(1E)-1-ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate |
| Synonym |
Corvaton; Corvasal; Molsidolat; Morial; Motazominn |
| Melting Point |
140-141°C |
| Solubility |
Soluble in chloroform, methanol, ethanol, or ethyl acetate. Slightly soluble in water, acetone or benzene. |
| Appearance |
White Crystal Powder |
Harnek J, Zoucas E, de Sá VP, et al. Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway. BMC Cardiovasc Disord. 2011 Jun 11;11:30. PMID: 21663688.
Won KJ, Lee P, Jung SH, et al. 3-morpholinosydnonimine participates in the attenuation of neointima formation via inhibition of annexin A2-mediated vascular smooth muscle cell migration. Proteomics. 2011 Jan;11(2):193-201. PMID: 21204247.
Cardoso MH, Morganti RP, Lilla S, et al. The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion. Eur J Pharmacol. 2010 Feb 10;627(1-3):229-34. PMID: 19895807.
