Methylprednisolone
Methylprednisolone is a synthetic glucocorticoid that displays anti-inflammatory and immunosuppressive activities. In vitro, methylprednisolone decreases survival of activated CD4+ T cells. In glioblastoma cells, this compound inhibits oxidative stress-induced apoptosis. Additionally, methylprednisolone decreases infiltration of immune cells and suppresses release of inflammatory cytokines in animal models of inflammation.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18944617
| Cas No. |
83-43-2 |
|---|---|
| Purity |
≥96% |
| Formula |
C22H30O5 |
| Formula Wt. |
374.47 |
| Chemical Name |
(6α,11β)-11,17,21-Trihydroxy-6-methylpregna-1,4- diene-3,20-dione |
| IUPAC Name |
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one |
| Synonym |
Medrate; Medrol; Medrone; Urbason |
| Melting Point |
228-237°C |
| Solubility |
Slightly soluble in ethanol (10 mg/mL), dioxane, acetone, or chloroform. Insoluble in water. |
| Appearance |
White to off white powder |
Lu YS, Pu LY, Li XC, et al. Methylprednisolone inhibits activated CD4+ T cell survival promoted by toll-like receptor ligands. Hepatobiliary Pancreat Dis Int. 2010 Aug;9(4):376-83. PMID: 20688601.
Das A, Banik NL, Ray SK. Methylprednisolone and indomethacin inhibit oxidative stress mediated apoptosis in rat C6 glioblastoma cells. Neurochem Res. 2007 Nov;32(11):1849-56. PMID: 17570061.
Sloka JS, Stefanelli M. The mechanism of action of methylprednisolone in the treatment of multiple sclerosis. Mult Scler. 2005 Aug;11(4):425-32. PMID: 16042225.
