Met-Enkephalin
Met-enkephalin is an endogenous opioid peptide that acts as an agonist at μ-opioid receptors (μORs) and δ-opioid receptors (δORs). Met-enkephalin exhibits neuromodulatory, antinociceptive/analgesic, antidepressant, and gastrointestinal motility modulating activities. Like other endogenous opioids, met-enkephalin modulates expression of opioid receptors and plays a role in reward/reinforcement signaling. Met-enkephalin is also involved in exercise-induced reversal of neuropathic pain and in animals undergoing the forced swim test, decreases immobility time. Met-enkephalin inhibits gastrointestinal muscle contractility, inhibiting motility and gastric emptying. Additionally, analogs of this peptide display anticancer and antiepileptic/anticonvulsant activities.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18943919
| Cas No. |
58569-55-4 |
|---|---|
| Purity |
≥95% |
| Formula |
C27H35N5O7S |
| Formula Wt. |
573.67 |
| IUPAC Name |
2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid |
| Synonym |
Metenkefalin, Opioid growth factor, 1-5-Adrenorphin (human) |
| Appearance |
White to off white powder |
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