Melphalan
Melphalan is a nitrogen mustard alkylator and a derivative of mechlorethamine. Melphalan exhibits anticancer chemotherapeutic activity, attaching alkyl groups to the N7 nitrogen of guanine bases on DNA, preventing DNA and RNA synthesis.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18943639
| Cas No. |
148-82-3 |
|---|---|
| Purity |
≥94% |
| Formula |
C13H18Cl2N2O2 |
| Formula Wt. |
305.20 |
| Chemical Name |
4-[Bis(2-chloroethyl)amino]-L-phenylalanine |
| IUPAC Name |
(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid |
| Synonym |
L-PAM; L-Phenylalanine mustard; L-Sarcolysine; Alkeran; Sarcoclorin |
| Melting Point |
180-181°C |
| Solubility |
Soluble in ethanol or propylene glycol. Practically insoluble in water. |
| Appearance |
White to Yellow Powder |
Polavarapu A, Stillabower JA, Stubblefield SG, et al. The mechanism of guanine alkylation by nitrogen mustards: a computational study.
J Org Chem. 2012 Jul 20;77(14):5914-21. PMID: 22681226.
Falco P, Bringhen S, Avonto I, et al. Melphalan and its role in the management of patients with multiple myeloma.
Expert Rev Anticancer Ther. 2007 Jul;7(7):945-57. PMID: 17627453.
