Melittin
Melittin is an antimicrobial peptide (AMP) found in Apis mellifera venom that exhibits antifungal, antibacterial, antiviral, and anti-parasitic activities. In Candida, melittin increases formation of radicals, decreases the mitochondrial membrane potential, and increases release of Ca2+ from the endoplasmic reticulum, inducing apoptosis and death. Like other AMPs, melittin induces pore formation in cell membranes, causing ion leakage. Melittin exhibits antimicrobial activity against Leishmania and Trypanosoma, inducing autophagy and apoptosis.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18943485
| Cas No. |
20449-79-0 |
|---|---|
| Purity |
≥98% |
| Formula |
C131H229N39O31 |
| Formula Wt. |
2846.5 |
| Synonym |
Mellitin; Melitten I, Forapin |
| Solubility |
Soluble in water (5mg/mL) or PBS (5mg/mL). |
| Appearance |
White to off white powder |
Lee J, Lee DG. Melittin triggers apoptosis in Candida albicans through the reactive oxygen species-mediated mitochondria/caspase-dependent pathway. FEMS Microbiol Lett. 2014 Apr 27. [Epub ahead of print]. PMID: 24766524.
Lee MT, Sun TL, Hung WC, et al. Process of inducing pores in membranes by melittin. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14243-8. PMID: 23940362.
Adade CM, Oliveira IR, Pais JA, et al. Melittin peptide kills Trypanosoma cruzi parasites by inducing different cell death pathways. Toxicon. 2013 Jul;69:227-39. PMID: 23562368.
